Effectiveness Of Intratympanic Gentamycin Injection In The Control Of Miniere’s Disease
Effectiveness Of Intratympanic Gentamycin Injection In The Control Of Miniere’s Disease
ISSN: 2757-976X ;
E-ISSN: 2757-976X ;
- Year : 2023
- Vol : 3
- No : 2
- Page : 72-74
ÖZ
ABSTRACT
Purpose: The effectiveness of intratympanic gentamicin (ITG) injection in controlling vertigo and the problems encountered in medically resistant Meniere's patients were investigated.
Materyal ve Metod: Files were reviewed retrospectively between 2000 and 2015. Twelve patients who were diagnosed with Meniere's disease in our clinic and who had ITG injection were included in the study. The diagnosis of Meniere's disease was made in these patients according to the criteria of the American Academy of Otolaryngology Head and Neck Surgery. Patients who underwent ITG were patients with severe sensorineural hearing loss (> 60 dB) unresponsive to medical treatment for at least 6 months. ITG was applied to the symptomatic ear in the bilateral affected patients. ITG was administered to these patients for 5 consecutive days at a dose of 40 mg/dl, 0.5-1 cc. The patients were evaluated according to American Academy of Otolaryngology-Head and Neck Surgery (AAO-HNS)vertigo recovery criteria 6 months after the last injection.
Results: The number of patients with complete and significant control of vertigo was 11 (92%). Partial control was achieved in one (8%) patient. Tinnitus control was successful in 5 (41%) patients, and aural fullness control was successful in 8 (66%) patients. Acute vestibular insufficiency and vestibular deafferentation syndrome developed in 10 (81%) patients. Injection-related complications such as myringitis, infection, perforation were not observed.
Conclusion: Intratympanic injections for vertigo control in Meniere's disease seem to be safe, inexpensive, effective and easily applied methods. There is a need for clinical and experimental studies for a specific algorithm on the dose, application period and method of gentamicin administered intratympanically.
Key words: Meniere's disease, vertigo, intratympanic injection, gentamicin
Purpose: The effectiveness of intratympanic gentamicin (ITG) injection in controlling vertigo and the problems encountered in medically resistant Meniere's patients were investigated.
Materyal ve Metod: Files were reviewed retrospectively between 2000 and 2015. Twelve patients who were diagnosed with Meniere's disease in our clinic and who had ITG injection were included in the study. The diagnosis of Meniere's disease was made in these patients according to the criteria of the American Academy of Otolaryngology Head and Neck Surgery. Patients who underwent ITG were patients with severe sensorineural hearing loss (> 60 dB) unresponsive to medical treatment for at least 6 months. ITG was applied to the symptomatic ear in the bilateral affected patients. ITG was administered to these patients for 5 consecutive days at a dose of 40 mg/dl, 0.5-1 cc. The patients were evaluated according to American Academy of Otolaryngology-Head and Neck Surgery (AAO-HNS)vertigo recovery criteria 6 months after the last injection.
Results: The number of patients with complete and significant control of vertigo was 11 (92%). Partial control was achieved in one (8%) patient. Tinnitus control was successful in 5 (41%) patients, and aural fullness control was successful in 8 (66%) patients. Acute vestibular insufficiency and vestibular deafferentation syndrome developed in 10 (81%) patients. Injection-related complications such as myringitis, infection, perforation were not observed.
Conclusion: Intratympanic injections for vertigo control in Meniere's disease seem to be safe, inexpensive, effective and easily applied methods. There is a need for clinical and experimental studies for a specific algorithm on the dose, application period and method of gentamicin administered intratympanically.
Key words: Meniere's disease, vertigo, intratympanic injection, gentamicin
Correspondence Address :
Email : [email protected]
Cite this Article As : Dündar MA, Özçelik Erdem R, Gül Z, Arbağ H. Meniere Hastalarında İntratimpanik Gentamisin Enjeksiyonunun Vertigo Kontrolünü Sağlamadaki Etkinliği. Mev Med Sci. 2023;3(2): 72-74
Description : Yazarların hiçbiri, bu makalede bahsedilen herhangi bir ürün, aygıt veya ilaç ile ilgili maddi çıkar ilişkisine sahip değildir. Araştırma, herhangi bir dış organizasyon tarafından desteklenmedi.Yazarlar çalışmanın birincil verilerine tam erişim izni vermek ve derginin talep ettiği takdirde verileri incelemesine izin vermeyi kabul etmektedirler. None of the authors, any product mentioned in this article, does not have a material interest in the device or drug. Research, not supported by any external organization. grant full access to the primary data and, if requested by the magazine they agree to allow the examination of data.
Email : [email protected]
Cite this Article As : Dündar MA, Özçelik Erdem R, Gül Z, Arbağ H. Meniere Hastalarında İntratimpanik Gentamisin Enjeksiyonunun Vertigo Kontrolünü Sağlamadaki Etkinliği. Mev Med Sci. 2023;3(2): 72-74
Description : Yazarların hiçbiri, bu makalede bahsedilen herhangi bir ürün, aygıt veya ilaç ile ilgili maddi çıkar ilişkisine sahip değildir. Araştırma, herhangi bir dış organizasyon tarafından desteklenmedi.Yazarlar çalışmanın birincil verilerine tam erişim izni vermek ve derginin talep ettiği takdirde verileri incelemesine izin vermeyi kabul etmektedirler. None of the authors, any product mentioned in this article, does not have a material interest in the device or drug. Research, not supported by any external organization. grant full access to the primary data and, if requested by the magazine they agree to allow the examination of data.
Effectiveness Of Intratympanic Gentamycin Injection In The Control Of Miniere’s Disease, strArastirmaMakalesi,
2023, Vol. 3 (2)
2023, Vol. 3 (2)
Received :30.05.2023,
Accepted : 07.08.2023,
Published Online : 15.08.2023
Mevlana Medical Sciences Journal
ISSN: 2757-976X ;
E-ISSN: 2757-976X ;
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Keywords
meniere's disease, vertigo, intratympanic injection, gentamicin