CPAP Treatment Contributes to Some Neuropeptide and Weight Change in Patients with Obstructive Sleep Apnea
- Year : 2023
- Vol : 3
- No : 1
- Page : 22-26
Aim: It was aimed to investigate whether there is a relationship between hypothalamic nutrition regulatory neuropeptides Neuropeptide Y (NPY), Orexin, pro-opiomelanocortin (POMC) and leptin levels in the emergence of obesity associated with OSAS and the weight change observed with PAP treatment.
Materials and Methods: Thirty-eight male volunteer patients aged 18-65 who were diagnosed with OSAS and planned for PAP treatment in the sleep laboratory of Chest Diseases were included in the study. Blood samples were taken from the patients after the diagnosis of OSAS and 6 months after PAP treatment. Neuropeptide levels were determined by ELISA method.
Results: Thirty-eight male patients the mean age was 47.82±1.64 years. Leptin, NPY, Orexin and POMC levels were lower and statistically significant in OSAS patients after 6 months of PAP treatment, independent of body mass index (BMI) (p>0.001).
Conclusion: We think that metabolic stability is achieved by eliminating apneas, providing oxygenation, correcting sleep fragmentation with PAP therapy, reducing the hypoxic effect and accordingly inflammation to a large extent. As a result, ensuring and encouraging the uninterrupted use of PAP devices by patients throughout the night will highlight the effectiveness of the treatment. In addition, giving diet and exercise programs while using the device will be effective in lowering BMIs for overweight patients.
Key words: CPAP, leptin, NPY, POMC, orexin, sleep apnea
Email : [email protected]
Cite this Article As : Vatansev H, Küççüktürk S, Karaselek MA, Arpacı N, Kılınç İ, Ak M. POMC, Orexin, NPY and Leptin Plasma Levels in Patients with Obstructive Sleep Apnea and Effect of CPAP Treatment. Mev Med Sci. 2023;3(1): 22-26
Description : Yazarların hiçbiri, bu makalede bahsedilen herhangi bir ürün, aygıt veya ilaç ile ilgili maddi çıkar ilişkisine sahip değildir. Araştırma, herhangi bir dış organizasyon tarafından desteklenmedi.Yazarlar çalışmanın birincil verilerine tam erişim izni vermek ve derginin talep ettiği takdirde verileri incelemesine izin vermeyi kabul etmektedirler. None of the authors, any product mentioned in this article, does not have a material interest in the device or drug. Research, not supported by any external organization. grant full access to the primary data and, if requested by the magazine they agree to allow the examination of data.
2023, Vol. 3 (1)
ISSN: 2757-976X ;
E-ISSN: 2757-976X ;
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Keywords
cpap, leptin, npy, pomc, orexin, sleep apnea