Bone marrow involvement pattern in lymphomas
- Year : 2022
- Vol : 2
- No : 1
- Page : 22-26
ABSTRACT
Aim: Detection of bone marrow involvement in patients with lymphoma is an important step in clinical staging, treatment and follow-up. In this study, it was aimed to evaluate the relationship between lymphoma subtypes and bone marrow infiltration patterns.
Methods: Biopsy samples of 102 lymphoma cases evaluated histopathologically and diagnosed with bone marrow infiltration in Necmettin Erbakan University Meram Faculty of Medicine Medical Pathology Laboratory between 2016 – 2021 were reviewed. Sections were re-evaluated by 3 observers for infiltration patterns, lymphoma subtypes and infiltration patterns were recorded.
Results: The most common lymphoma subtypes were diffuse large B cell lymphoma (22.3%) and mantle cell lymphoma (22.3%), followed by T cell lymphoma (15.5%), follicular lymphoma (9.7%), chronic lymphocytic leukemia/small lymphocytic lymphoma (4.8%), Hodgkin lymphoma (4.8%), lymphoblastic lymphoma (1.9%), Burkitt lymphoma, MALT lymphoma, marginal zone lymphoma (0.94%), lymphoma of undetermined subtype (9.7%). Involvement patterns encountered were diffuse, paratrabecular, interstitial, nodular and mixed infiltration. In all cases the mixed type infiltration pattern was the most common with 29.1%. Mixed pattern, on the other hand, mostly included nodular and interstitial involvement together. The most common pattern as a single type was the diffuse pattern. The involvement patterns in diffuse large B cell lymphoma and mantle cell lymphoma, where the most common involvement was detected: 34.7% diffuse, 26% nodular, 17.4% mixed, 17.4% interstitial, 4.4% paratrabecular in diffuse large B cell lymphoma; 47.8% mixed, 21.7% diffuse, 17.4% paratrabecular, 13% nodular infiltration patterns in mantle cell lymphoma.
Conclusion: The mixed infiltration pattern was most common in mantle cell lymphoma, but was not specific as it was also seen in other lymphomas. In follicular lymphoma in which the paratrabecular pattern is prominent, other involvement patterns were also encountered. Based on the infiltration pattern, it is not possible to say definitively which lymphoma subtype the involvement observed in the bone marrow is associated with. For this, it is essential to refer to ancillary tests in determining the lymphoma type.
Key words: Bone marrow, Lymphoma, Infiltration, Pattern
Email : [email protected]
Cite this Article As : Gültekin A, Atlamaz E, Kılınç F, Tas Ayçiçek S, Oltulu P. Lenfomalarda Kemik İliği Tutulum Paterni. Mev Med Sci. 2022;2(1): 22-26
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2022, Vol. 2 (1)
ISSN: 2757-976X ;
E-ISSN: 2757-976X ;
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Keywords
bone marrow, lymphoma, infiltration, pattern