The effect of the vaccination status of RT-PCR+ Covid-19 cases on albumin, N/L Ratio, CRP, and D-dimer levels

ABSTRACT

Aim: SARS-CoV-2 is the cause of a pandemic with high mortality rates affecting the entire world. In the present study, N/L Ratios, CRP, and D-dimer levels were investigated in patients who were diagnosed with RT-PCR+ Covid-19 again despite receiving the Biontech and Sinovac vaccines.

Materials and Methods: The retrospective study was conducted with a total of 114 patients (n=114) and a healthy control group (n=60) who had 43 Biontech and 71 Sinovac vaccines but were diagnosed with RT-PCR+ Covid-19 again. Subjects who were vaccinated with Biontech or Sinovac and whose RT-PCR Test (Real-Time Polymerized Chain Reaction) was positive were included in the study. The routine biochemistry, serology, and hormone test results of the patients were compared with those of the Control Group. The data were analyzed on the computer with the SPSS22 program.

Results: CRP, N/L, and D-dimer levels were higher in the 2 vaccinated groups at statistically significant levels when compared to the control group, but higher values were detected in the Sinovac Group (p<0.001). Albumin levels were found to be lower in the vaccinated groups when compared to the Control Group (p<0.001). Procalcitonin, AST, LDH, and lipase levels were significantly higher in the vaccinated groups when compared to the Control Group, while lymphocyte levels were lower in the vaccinated groups (p<0.001).

Conclusion: Although N/L ratios, CRP, and D-dimer levels were higher in the Sinovac vaccine group than in the Control Group, albumin levels were lower in patients who were diagnosed with RT-PCR+ Covid-19 again despite having Biontech and Sinovac vaccines.

Key words: Covid-19; Biontech; Sinovac; N/L, CRP, D-dimer