Does Pregabalin Affect Renal Functions and Plasma Electrolytes?
Does Pregabalin Affect Renal Functions and Plasma Electrolytes?
ISSN: 2757-976X ;
E-ISSN: 2757-976X ;
- Year : 2024
- Vol : 4
- No : 2
- Page : 74-80
ÖZ
Aim: It is known that the half-life of pregabalin increases with age. This may be related to the decline in kidney function with age. In this study, it was aimed to investigate the neurotoxicity and renal toxicity that pregabalin may cause.
Materials and Methods: 100 patients followed up in the Department of Neurology between 2019-2020 were included for the study.It was planned to scan the hospital files of the adult patient group using pregabalin. The data obtained as a result of possible changes in serum electrolyte levels and kidney functions of patients with pregabalin indication were evaluated. Peripheral blood urea, uric acid, creatinine, serum electrolyte levels of the patients were determined and glomerular filtration rate (GFR) was analyzed twice, in six months for possible changes in kidney functions.
Results: Arithmetic mean values and changes were examined in patients who were measured twice in a six-month period. The effect of pregabalin use on urea and uric acid values, which are markers of renal function, was found to be statistically significant (p<0.05). There was no statistically significant effect on GFR, creatinine, Na+, Cl–, K+, Ca+2, Mg+2 and P+3 parameters (p>0.05).
Conclusion: This study may be useful to investigate the effects of pregabalin on other organs. The data obtained may contribute to the provision of information that may be useful to drug research and development institutions and to increase drug safety.
Materials and Methods: 100 patients followed up in the Department of Neurology between 2019-2020 were included for the study.It was planned to scan the hospital files of the adult patient group using pregabalin. The data obtained as a result of possible changes in serum electrolyte levels and kidney functions of patients with pregabalin indication were evaluated. Peripheral blood urea, uric acid, creatinine, serum electrolyte levels of the patients were determined and glomerular filtration rate (GFR) was analyzed twice, in six months for possible changes in kidney functions.
Results: Arithmetic mean values and changes were examined in patients who were measured twice in a six-month period. The effect of pregabalin use on urea and uric acid values, which are markers of renal function, was found to be statistically significant (p<0.05). There was no statistically significant effect on GFR, creatinine, Na+, Cl–, K+, Ca+2, Mg+2 and P+3 parameters (p>0.05).
Conclusion: This study may be useful to investigate the effects of pregabalin on other organs. The data obtained may contribute to the provision of information that may be useful to drug research and development institutions and to increase drug safety.
Correspondence Address :
NECMETTİN ERBAKAN ÜNİVERSİTESİ FİZYOLOJİ ANABİLİM DALI
Email : [email protected]
Cite this Article As : Gunay AC, Ozen Koca R, Akgul Gunay M, Ozdengul F, Solak Gormus ZI. Does Pregabalin Affect Renal Functions and Plasma Electrolytes? Mev Med Sci. 2024; 4(2): 74-80
Description : Yazarların hiçbiri, bu makalede bahsedilen herhangi bir ürün, aygıt veya ilaç ile ilgili maddi çıkar ilişkisine sahip değildir. Araştırma, herhangi bir dış organizasyon tarafından desteklenmedi.Yazarlar çalışmanın birincil verilerine tam erişim izni vermek ve derginin talep ettiği takdirde verileri incelemesine izin vermeyi kabul etmektedirler. None of the authors, any product mentioned in this article, does not have a material interest in the device or drug. Research, not supported by any external organization. grant full access to the primary data and, if requested by the magazine they agree to allow the examination of data.
Email : [email protected]
Cite this Article As : Gunay AC, Ozen Koca R, Akgul Gunay M, Ozdengul F, Solak Gormus ZI. Does Pregabalin Affect Renal Functions and Plasma Electrolytes? Mev Med Sci. 2024; 4(2): 74-80
Description : Yazarların hiçbiri, bu makalede bahsedilen herhangi bir ürün, aygıt veya ilaç ile ilgili maddi çıkar ilişkisine sahip değildir. Araştırma, herhangi bir dış organizasyon tarafından desteklenmedi.Yazarlar çalışmanın birincil verilerine tam erişim izni vermek ve derginin talep ettiği takdirde verileri incelemesine izin vermeyi kabul etmektedirler. None of the authors, any product mentioned in this article, does not have a material interest in the device or drug. Research, not supported by any external organization. grant full access to the primary data and, if requested by the magazine they agree to allow the examination of data.
Does Pregabalin Affect Renal Functions and Plasma Electrolytes?, strArastirmaMakalesi,
2024, Vol. 4 (2)
2024, Vol. 4 (2)
Received :13.02.2024,
Accepted : 06.05.2024,
Published Online : 07.08.2024
Mevlana Medical Sciences Journal
ISSN: 2757-976X ;
E-ISSN: 2757-976X ;
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Keywords
renal function, pregabalin, renal toxicity, creatinine