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Occurrence of hematological diseases in patients with intraabdominal venous thrombosis and evaluation of PNH

Kübra Yel Uygun,Ali Erkan Duman,Şule Poturoğlu,Mesut Ayer

  • Mesut Ayer: BAŞAKŞEHİR ÇAM SAKURA ŞEHİR HASTANESİ
  •  Year : 2025
  •  Vol : 5
  •  Issue : 1
  •  Page : 11-17
Introduction: This study aims to describe the clinical, demographic, and laboratory characteristics of patients with abdominal venous thrombosis (AVT) and investigate the presence of paroxysmal nocturnal hemoglobinuria (PNH) clones. AVT is a rare but significant condition that affects various anatomical regions, including portal vein thrombosis (PVT), renal vein thrombosis (RVT), mesenteric vein thrombosis (MVT), and splenic vein thrombosis (SVT). Understanding the role of hematological diseases, including PNH, in the development of AVT may provide insight into its underlying mechanisms. Method: This retrospective case series was conducted at a tertiary research hospital. The study cohort consisted of adult patients diagnosed with and treated for intra-abdominal venous thrombosis. Data were collected from hospital information management system records. Demographic and clinical variables such as age, sex, thrombosis location, comorbidities, prothrombotic conditions, and genetic mutations were recorded. PNH clone presence was assessed for each patient using flow cytometry. Results: Data from 32 patients were analyzed. The mean age was 45 ± 15.6 years. Isolated PVT was observed in 21 patients (65.6%), while 4 (12.5%) had both PVT and RVT. MVT was observed in 1 patient (3.1%), and SVT in 2 patients (6.3%). Of the 3 patients with Budd-Chiari syndrome, 2 had SVT. Comorbidities included cirrhosis (6 patients), polycythemia vera (1), Factor V Leiden mutation (1), and protein C deficiency (2). No patient had a prior history of malignancy. Conclusion: There was no significant difference between male and female patients regarding risk factors, comorbidities, and multi-vessel thrombosis. No PNH clones were detected in any patient, suggesting a limited role for PNH in AVT pathogenesis. Further studies with larger cohorts are required to confirm these findings.
Cite this Article As : Yel Uygun K, Duman AE, Poturoglu S, Ayer M. Occurrence of hematological diseases in patients with intraabdominal venous thrombosis and evaluation of PNH. Mev Med Sci. 2025; 5(1): 11-17

Conflict of interest : The authors declare that they have no conflict of interest.

This article is published under the CC BY-NC 4.0 license.
Mevlana Tıp Bilimleri
2025, Vol5, Issue1
E-ISSN: 2757-976X
Received : , Accepted : , Published Online :

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