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Effect of ozone therapy on pain, depression and quality of life in patients with fibromyalgia syndrome

AHMET KARAKOYUN,YALKIN ÇALIK,GAMZE YANARTAŞ

  •  Year : 2023
  •  Vol : 3
  •  Issue : 3
  •  Page : 115-120
ABSTRACT
Aim: In this study, we aimed to investigate the effect of ozone therapy on pain, depression and quality of life in patients with fibromyalgia syndrome (FMS).

Materials and Method: A total of 70 female patients aged 18-65 who were diagnosed with FMS and received ozone therapy in addition to physiotherapy were included in the study. Demographic data such as age, gender, and clinical parameters such as Visual Analague Scalae(VAS), Beck Depression Index(BDI) and Fibromyalgia Impact Questionnaire(FIQ) were analyzed retrospectively. Patients were divided into two groups as the ozone and control groups. Patients in the control group were administered classical physical therapy (hotpack, TENS) for three weeks. Whereas, the major autohemotherapy method was applied in the ozone therapy group simultaneously with the classical physical therapy again for three weeks. Both groups were compared in terms of VAS for pain severity, BDI for depression, and FIQ for quality of life in before and after the treatment.

Results: There was no significant difference between age (36,68±2,84/35,85±3,77) (p:0,626) and body mass index (BMI) (23,78±2,41/23,65±2,70) (p:0,728) between the ozone and the control group respectively. Pain severity (p<0,001), depression (p<0,001) and quality of life (p<0,001) were significantly improved after treatment in both groups compared the before treatment, while better improvement was observed in the ozone group after treatment (p<0,001).

Conclusion: Our study demonstrated that ozone therapy has better effects on pain severity, depression and quality of life in patients with FMS. Therefore it can be added to treatment safely.
Cite this Article As : Karakoyun A, Yalkın Y, Yanartaş G. Effect of Ozone Therapy on Pain, Depression and Quality of Life in Patients with Fibromyalgia Syndrome. Mev Med Sci. 2023;3(3):115-120

Conflict of interest : The authors declare that they have no conflict of interest.

This article is published under the CC BY-NC 4.0 license.
Mevlana Tıp Bilimleri
2023, Vol3, Issue3
E-ISSN: 2757-976X
Received : , Accepted : , Published Online :

References

  1. 1. Hauser W, Zimmer C, Felde E, Kollner V. What are the key symptoms of fibromyalgi asyndrome? Results of a survey of the German Fibromyalgia Association. Schmerz 2008;22:176‐83.
  2. 2. Ata AM, Çetin A. Fibromiyalji Tanımı, Epidemiyolojisi: Türkiye Klinikleri JPM&R-Special Topics 2015; 8(3): 1-4
  3. 3. Ajamieh H, Merino N, Candelario-Jalil E, et al. Similar protective effect of ischaemia and ozone oxidative preconditionings in liver ischaemia/reperfusion injury. Pharmacological Research 2002; 45: 333-339.
  4. 4. Saime AY, Tur BS, Evcik D. Kas İskelet Sistemi Hastalıklarında Sık Uygulanan Geleneksel Ve Tamamlayıcı Tıp Uygulamaları. Kocatepe Tıp Dergisi, 2019;20(3), 147-156.
  5. 5. Dıraçoğlu D. Ozone-oxygen therapies in musculoskeletal diseases/Kas iskelet hastaliklarinda ozon-oksijen tedavileri. Turkish Journal of Physical Medicine and Rehabilitation. 2016;62.2: 183-192.
  6. 6. Korkut Y, Ayada C, Toru Ü. Ozone Therapy and Its Effect on Cervical-Lumbar Disc Herniation. Ankara Medical Journal, 2015; 15(3): 161-168
  7. 7. Kızıl R. Servikal Disk Hernileri. Türkiye Klinikleri J PM&R-Special Topics 2009;2:35-43.
  8. 8. Alper S. Lomber Disk Hernileri. Türkiye Klinikleri J PM&R-Special Topics 2011;4:32-43.
  9. 9. Terapi Ozon. Turk J Integr Med, 2015;3(1): 21-26.
  10. 10. Erdine S. Ağrı. Nobel Tıp Kitab evleri. Alemdar Ofset Savaş Ciltevi. 2000. İstanbul. 37-40.
  11. 11. Hisli N. Beck Depresyon Ölçeği’nin bir Türk örnekleminde geçerlilik ve güvenilirliği. Psikoloji Dergisi 1988;6:118‐22
  12. 12. Sarmer S, Ergin S, Yavuzer G. The validity and realibility of the Turkish version of the Fibromyalgia impact questionnaire. Rheumatol Int. 2000;20:9‐12.
  13. 13. Özkan N. Fibromyalji sendromunda bütüncül yaklaşım. Bilimsel Tamamlayıcı Tıp Regülasyon ve Nöral Terapi Dergisi, 2017;11(1): 12-19.
  14. 14. Cetin N. Factors affecting the quality of life in patients with fibromyalgia. Turk J Rheumatol 2009;24:77‐81
  15. 15. Bocci V, Valacchi G, Corradeschi F, et al. Studies on the biological effects of ozone: VII. Generation of reactive oxygen species (ROS) after exposure of human blood to ozone. Journal of Biological Regulators and Homeostatic Agents 1998; 12: 67-75.
  16. 16. Bocci V, Borrelli E, Zanardi I, et al. The usefulness of ozone treatment in spinal pain. Drug design, development and therapy, 2015;9: 2677-2685.
  17. 17. Magalhaes FN, Dotta L, Sasse A, Teixera MJ, Fonoff ET. Ozone therapy as a treatment for low back pain secondary to herniated disc: a systematic review and meta-analysis of randomized controlled trials. Pain Physician. 2012;15:E115–E129
  18. 18. Özcan Ç, Polat Ö, Çelik H, Uçar B. Y. (2019). The Effect of Paravertebral Ozone Injection in theTreatment of Low Back Pain. Pain Practice 2019;19(8): 821-825.
  19. 19. Borrelli E. Mechanism of action of oxygen ozone therapy in the treatment of disc herniation and low back pain. Acta Neurochir Suppl. 2011;108:123–125.
  20. 20. Giombini A, Menotti F, Di AC, Giovannangeli F, Rizzo M, Moffa S, Martinelli F. Comparison between intra articular injection of hyaluronicacid, oxygen ozone, and the combination of both in the treatment of knee osteoarthrosis. Journal of biological regulators and homeostaticagents. 2016; 30(2): 621-625.
  21. 21. Bonetti M, Fontana A, Martinelli F, Andreula C. Oxygen ozone the rapy for degenerative spine disease in the elderly: a prospective study. Acta Neurochir Suppl 2011;108:137–142.
  22. 22. Murphy K, Muto M, Steppan J, Meaders T, Boxley C. Treatment of contained herniated lumbar discs with ozone and corticosteroid: a pilot clinical study. Can Assoc Radiol J. 2015;66:377–384
  23. 23. Hidalgo-Tallón J, Menéndez-Cepero S, Vilchez JS, Rodríguez-López CM, Calandre EP. Ozone therapy as add-on treatment in fibromyalgia management by rectal insufflation: an open-label pilot study. The Journal of Alternative and Complementary Medicine. 2013;19(3), 238-242.
  24. 24. Tirelli U, Cirrito C, Pavanello M. Ozonetherapy in 40 patients with fibromyalgia: an effective therapy. Ozone Therapy. 2018; 3(3):43-45.
  25. 25. Tirelli U, Cirrito C, Pavanello M, Piasentin C, Lleshi A,Taibi R. Ozone therapy in 65 patients with fibromyalgia: an effective therapy. Eur Rev Med Pharmacol Sci 2019;23(4): 1786-1788.
  26. 26. Moreno-Fernández AM, Macías-García L, Valverde-Moreno R, Ortiz T, Fernández-Rodríguez A, Moliní-Estrada A. Auto hemotherapy with ozone as a possible effective treatment for Fibromyalgia. Acta Reumatológica Portuguesa. 2019; 44(3): 244-249
  27. 27. Çapacı K, Hepgüler S. Fibromyalji Sendorumu: Etiyopatogenez. Ege Fiz Tıp Reh Der. 1998; 4(3): 219-226.