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Candida-Associated Urinary Tract Infections in Children: A Single-Center Experience

Mustafa GENÇELİ,arif,Kübra Nur Erdoğan,Sipil Gençeli,ABDULLAH AKKUŞ,ÖZGE METİN AKÇAN,METİN DOĞAN

  • Mustafa GENÇELİ: KONYA NECMETTİN ERBAKAN ÜNİVERSİTESİ
  • Kübra Nur Erdoğan: NEU Faculty of Medicine
  • ABDULLAH AKKUŞ: NECMETTİN ERBAKAN ÜNİ. MERAM TIP FAK.
  • METİN DOĞAN: N.ERBAKAN ÜN.
  •  Year : 2025
  •  Vol : 5
  •  Issue : 1
  •  Page : 1-4
Introduction: The incidence of fungal infections, particularly those caused by Candida species, has been increasing globally. These infections are especially prevalent in nosocomial settings, affecting patients with predisposing conditions such as chronic illness, recent invasive procedures, admission to intensive care units (ICUs), and exposure to broad-spectrum antibiotics. This study aims to characterize the clinical presentation, laboratory findings, and risk factors associated with candiduria in a pediatric population. Materials and Methods: This retrospective study analyzed data from pediatric patients aged 1 month to 18 years diagnosed with candiduria at our institution between January 2017 and June 2024. Results: The study cohort comprised 58 pediatric patients (22 females, 36 males) with confirmed Candida species isolated from urine cultures. The mean age was 6.2 ± 2.9 years. Candida albicans was the most prevalent species, identified in 43 (74.1%) patients, followed by C. parapsilosis (13.7%), C. tropicalis (6.8%), C. lusitaniae (1.7%), C. lipolytica (1.7%), and C. krusei (1.7%). Clinical manifestations during candiduria episodes included fever (55.1%), dysuria (46.5%), flank pain (15.5%), suprapubic tenderness (13.7%), urinary frequency (12%), and urgency (6.8%). The most frequently observed risk factors among these patients were urinary catheterization (63.7%), ICU admission (60.3%), prolonged antibiotic use (58.6%), and the presence of a central venous catheter (56.8%). Laboratory findings revealed a mean leukocyte count of 12,964 ± 8,448/mm³, a neutrophil count of 8,297 ± 6,495/mm³, a urea level of 29.3 ± 26.3 mg/dL, a creatinine level of 0.49 ± 0.29 mg/dL, and a C-reactive protein level of 34.2 ± 25.3 mg/L. Antifungal therapy consisted of fluconazole in 57 patients and caspofungin in 1 patient. Conclusion: Effective management of candiduria requires a thorough understanding of local epidemiological trends and patient-specific risk factors. In pediatric patients, candiduria, particularly when accompanied by multiple risk factors, necessitates careful clinical evaluation and tailored treatment strategies.
Cite this Article As : Genceli M, Erdogan AC, Erdogan KN, Genceli S, Akkus A, Akcan Metin O, Dogan M. Candida-Associated Urinary Tract Infections in Children: A Single-Center Experience. Mev Med Sci. 2025; 5(1): 1-4

Conflict of interest : The authors declare that they have no conflict of interest.

This article is published under the CC BY-NC 4.0 license.
Mevlana Tıp Bilimleri
2025, Vol5, Issue1
E-ISSN: 2757-976X
Received : , Accepted : , Published Online :

References

  1. 1) Ekinci F, Yildizdas D, Horoz OO, Ozgur Gundeslioglu O, Alabaz D. Treatment of Candida urinary tract infections with micafungin in children. Pediatr Int 2022;64:15033.
  2. 2) Nayman Alpat S, Özguneş I, Ertem OT, Erben N, Doyuk Kartal E, Tözun M et al. Kandidürisi Olan Hastalarda Risk Faktörlerinin Değerlendirilmesi. Mikrobiyol Bul 2011; 45:318-24.
  3. 3) Shuman EK, Chenoweth CE. Recognition and prevention of healthcare-associated urinary tract infections in the intensive care unit. Crit Care Med. 2010;3:373-9.
  4. 4) Lundstrom T, Sobel J. Nosocomial candiduria: a review. Clin Infect Dis 2001;32:1602-7.
  5. 5)Atalay MA, Sav H, Demir G, Koç AN. Kan Kültürlerinden İzole Edilen Candida Türlerinin Dağılımı Ve Amfoterisin B Ve Flukonazole İn Vitro Duyarlılıkları. Selçuk Tıp Derg 2012;28:149-51.
  6. 6) Carvalho M, Guimarães CM, Mayer JR Jr, Bordignon GP, Queiroz-Telles F. Hospital-associated funguria: analysis of risk factors, clinical presentation and outcome. Braz J Infect Dis. 2001;5:313-8.
  7. 7) Bektaş AD, Yasa EO, Habip Z, Koçoğlu E. Evaluation of risk factors in invasive Candida infections in children. J Pediatr Inf 2023;17:151-9.
  8. 8) Sutcu M, Salman N, Akturk H. Epidemiologic and microbiologic evaluation of nosocomial infections associated with Candida spp in children: A multicenter study from Istanbul, Turkey. Am J Infect Control 2016;44:1139–43.
  9. 9) Binelli CA, Moretti ML, Assis RS, Sauaia N, Menezes PR, Ribeiro E, et al. Investigation of the possible association between nosocomial candiduria and candidaemia. Clin Microbiol Infect 2006;12:538–43.
  10. 10) Brindha SM, Jayashree M, Singhi S, Taneja N. Study of nosocomial urinary tract infections in a pediatric intensive care unit. J Trop Pediatr 2011;57:357–62.
  11. 11) Shirvani F, Fattahi M. Molecular identification of Candida species isolated from candiduria and its risk factors in neonates and children. Curr Med Mycol 2021;7:9-12.
  12. 12) Robinson JL, Davies HD, Barton M, O'Brien K, Simpson K, Asztalos E, et al. Characteristics and outcome of infants with candiduria in neonatal intensive care - a Paediatric Investigators Collaborative Network on Infections in Canada (PICNIC) study. BMC Infect Dis 2009;9:183.
  13. 13) Alfouzan WA, Dhar R. Candiduria: Evidence-based approach to management, are we there yet? J Mycol Med 2017;27:293-302.